Isotretinoin (INN) (IPA: [ˌaɪsoʊˈtrɛtənoʊɪn]) is a medication used for the treatment of severe acne. It is sometimes used in prevention and treatment of certain skin cancers. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body.
Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilizes keratinization and prevents comedones from forming. The exact mechanism of action is unknown, however it is known that like other retinoids, Isotretinoin works by altering DNA transcription.[3] This effect decreases the size and output of sebaceous glands, makes the cells that are sloughed off into the sebaceous glands less sticky, and therefore less able to form comedones.
Sebaceous glands secrete an oily substance called sebum (Latin, meaning fat or tallow) that is made of fat (lipids) and the debris of dead fat-producing cells. In the glands, sebum is produced within specialized cells and is released as these cells burst; sebaceous glands are thus classified as holocrine glands.
Sebum is odorless, but its bacterial breakdown can produce odors. Sebum is the cause of some people experiencing "oily" hair if it is not washed for several days. Earwax is partly composed of sebum.
Sebum acts to protect and waterproof hair and skin, and keep them from becoming dry, brittle and cracked. It can also inhibit the growth of microorganisms on skin.
-----------------------------------
Accutane stops your skin from spitting out oil, its going to be a very very dry time.